Assay Detail
Binding
CHEMBL802718
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Inhibition of murine Retinoic acid receptor RAR alpha
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL46398 | — | — | 1 | 7.96 |
| CHEMBL75548 | — | — | 1 | 7.51 |
| CHEMBL2111557 | — | — | 2 | 6.05 |
| CHEMBL72988 | — | — | 1 | 5.98 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL46398 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL75548 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2111557 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL72988 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2111557 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL547 | ISOTRETINOIN | IC50 | > | 1000.0 | nM | - |