Assay Detail
Binding
CHEMBL802720
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Dissociation constant for binding to Retinoic acid receptor alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.05 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.15 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.82 |
| CHEMBL118268 | — | — | 1 | 6.00 |
| CHEMBL119781 | — | — | 1 | 5.39 |
| CHEMBL118693 | — | — | 1 | 5.00 |
| CHEMBL118307 | — | — | 1 | 5.00 |
| CHEMBL324960 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL38 | TRETINOIN | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL118268 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL119781 | — | Kd | = | 4081.0 | nM | 5.39 |
| CHEMBL118693 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL118307 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL324960 | — | Kd | = | 10000.0 | nM | 5.00 |