Assay Detail
Binding
CHEMBL802759
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In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT)
122
Total Activities
122
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 122 | 6.24 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL37628 | — | — | 1 | 7.46 |
| CHEMBL70629 | — | — | 1 | 7.44 |
| CHEMBL307220 | — | — | 1 | 7.42 |
| CHEMBL439943 | — | — | 1 | 7.40 |
| CHEMBL70719 | — | — | 1 | 7.21 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.08 |
| CHEMBL37842 | — | — | 1 | 7.02 |
| CHEMBL73672 | — | — | 1 | 6.96 |
| CHEMBL37343 | — | — | 1 | 6.90 |
| CHEMBL74690 | — | — | 1 | 6.85 |
| CHEMBL288305 | — | — | 1 | 6.77 |
| CHEMBL305965 | — | — | 1 | 6.77 |
| CHEMBL69894 | — | — | 1 | 6.77 |
| CHEMBL71311 | — | — | 1 | 6.72 |
| CHEMBL70483 | — | — | 1 | 6.70 |
| CHEMBL308248 | — | — | 1 | 6.64 |
| CHEMBL308686 | — | — | 1 | 6.64 |
| CHEMBL305521 | — | — | 1 | 6.62 |
| CHEMBL70850 | — | — | 1 | 6.62 |
| CHEMBL70255 | — | — | 1 | 6.54 |
| CHEMBL306032 | — | — | 1 | 6.46 |
| CHEMBL309574 | — | — | 1 | 6.44 |
| CHEMBL70312 | — | — | 1 | 6.42 |
| CHEMBL73845 | — | — | 1 | 6.42 |
| CHEMBL71927 | — | — | 1 | 6.40 |
| CHEMBL311349 | — | — | 1 | 6.39 |
| CHEMBL70930 | — | — | 1 | 6.38 |
| CHEMBL424046 | — | — | 1 | 6.37 |
| CHEMBL291024 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL37628 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL70629 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL307220 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL439943 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL70719 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL37842 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL73672 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL37343 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL74690 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL305965 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL69894 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL288305 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL71311 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL70483 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308686 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL308248 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL305521 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL70850 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL70255 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL306032 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL309574 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL73845 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL70312 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL71927 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL311349 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL70930 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL424046 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL291024 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL289816 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL290957 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL305010 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL312340 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL71023 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL302931 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL303466 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL70562 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL39950 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL310490 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL70743 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL290410 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL305416 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL73015 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL419629 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL418885 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL291113 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL72535 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL289429 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL71310 | — | IC50 | = | 2100.0 | nM | 5.68 |