Assay Detail
Functional
CHEMBL802807
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Tested for the antagonistic activity against serotonin-induced contractions in rat aorta ring strip of endothelium
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-HT2 antagonist activity of 3-aminomethyltetralones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.51 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.87 |
| CHEMBL308480 | — | — | 1 | 7.86 |
| CHEMBL310734 | — | — | 1 | 7.27 |
| CHEMBL72649 | — | — | 1 | 7.25 |
| CHEMBL310153 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | Kd | = | 1.349 | nM | 8.87 |
| CHEMBL308480 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL310734 | — | Kd | = | 53.7 | nM | 7.27 |
| CHEMBL72649 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL310153 | — | Kd | = | 512.86 | nM | 6.29 |