Assay Detail
Functional
CHEMBL802870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against prolactin release in rat anterior pituitary cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.77 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333795 | — | — | 1 | 10.22 |
| CHEMBL1275 | PERGOLIDE MESYLATE | 4.0 | 1 | 10.15 |
| CHEMBL148600 | — | — | 1 | 10.00 |
| CHEMBL347326 | — | — | 1 | 9.70 |
| CHEMBL330997 | — | — | 1 | 7.77 |
| CHEMBL147244 | — | — | 1 | 7.00 |
| CHEMBL121653 | — | — | 1 | 6.52 |
| CHEMBL359414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333795 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1275 | PERGOLIDE MESYLATE | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL148600 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL347326 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL330997 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL147244 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121653 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL359414 | — | IC50 | > | 10000.0 | nM | - |