Assay Detail
Functional
CHEMBL802960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for inhibition of 5-alpha-Dihydrotestosterone (DHT) stimulated shionogi cell proliferation was determined
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiandrogenic activity of 17-hydroxy-17-(-hydroxy/haloalkyn-1-yl)-4-methyl-4-aza-3-oxo-5-androstan-(1-ene)-3-ones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.83 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491 | HYDROXYFLUTAMIDE | 2.0 | 1 | 7.28 |
| CHEMBL275284 | — | — | 1 | 7.17 |
| CHEMBL9887 | — | — | 1 | 7.03 |
| CHEMBL417973 | — | — | 1 | 7.01 |
| CHEMBL268748 | — | — | 1 | 6.89 |
| CHEMBL276665 | — | — | 1 | 6.85 |
| CHEMBL275764 | — | — | 1 | 6.83 |
| CHEMBL273496 | — | — | 1 | 6.80 |
| CHEMBL10474 | — | — | 1 | 6.75 |
| CHEMBL9948 | — | — | 1 | 6.60 |
| CHEMBL10163 | — | — | 1 | 6.55 |
| CHEMBL10018 | — | — | 1 | 6.49 |
| CHEMBL273746 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491 | HYDROXYFLUTAMIDE | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL275284 | — | IC50 | = | 67.2 | nM | 7.17 |
| CHEMBL9887 | — | IC50 | = | 94.5 | nM | 7.03 |
| CHEMBL417973 | — | IC50 | = | 96.8 | nM | 7.01 |
| CHEMBL268748 | — | IC50 | = | 128.9 | nM | 6.89 |
| CHEMBL276665 | — | IC50 | = | 141.8 | nM | 6.85 |
| CHEMBL275764 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL273496 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL10474 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL9948 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL10163 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL10018 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL273746 | — | IC50 | = | 328.0 | nM | 6.48 |