Assay Detail
Binding
CHEMBL803260
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In vitro binding affinity towards serotonin 5-HT1A receptor by the displacement of [3H]8-OH-DPAT from rat hippocampus
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of n-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives as potential anti-ischemic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.68 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57606 | — | — | 1 | 7.52 |
| CHEMBL301642 | — | — | 1 | 7.34 |
| CHEMBL293292 | — | — | 1 | 7.30 |
| CHEMBL60814 | — | — | 1 | 7.15 |
| CHEMBL293364 | — | — | 1 | 6.97 |
| CHEMBL58601 | — | — | 1 | 6.89 |
| CHEMBL300150 | — | — | 1 | 6.84 |
| CHEMBL59006 | — | — | 1 | 6.59 |
| CHEMBL300556 | — | — | 1 | 6.54 |
| CHEMBL60859 | BMY-14802 | — | 1 | 6.50 |
| CHEMBL299046 | — | — | 1 | 6.50 |
| CHEMBL60872 | — | — | 1 | 6.46 |
| CHEMBL61304 | — | — | 1 | 6.38 |
| CHEMBL61303 | — | — | 1 | 6.34 |
| CHEMBL61177 | — | — | 1 | 6.25 |
| CHEMBL57297 | — | — | 1 | 6.24 |
| CHEMBL300351 | — | — | 1 | 5.74 |
| CHEMBL58283 | — | — | 1 | - |
| CHEMBL58282 | — | — | 1 | - |
| CHEMBL58566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57606 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL301642 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL293292 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL60814 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL293364 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL58601 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL300150 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL59006 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL300556 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL299046 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL60872 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL61304 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL61303 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL61177 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL57297 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL300351 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL58283 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL58282 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL58566 | — | IC50 | - | nM | - |