Assay Detail
Binding
CHEMBL803262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- 8-OH-DPAT binding to 5-HT1A-receptor from rat cerebral cortex membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT1A-receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.16 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87195 | — | — | 1 | 9.15 |
| CHEMBL90053 | — | — | 1 | 8.82 |
| CHEMBL316050 | — | — | 1 | 8.77 |
| CHEMBL87348 | — | — | 1 | 8.74 |
| CHEMBL315684 | — | — | 1 | 8.55 |
| CHEMBL89014 | — | — | 1 | 8.42 |
| CHEMBL86648 | — | — | 1 | 8.37 |
| CHEMBL87105 | — | — | 1 | 8.11 |
| CHEMBL88994 | — | — | 1 | 8.02 |
| CHEMBL88157 | — | — | 1 | 7.77 |
| CHEMBL88997 | — | — | 1 | 7.62 |
| CHEMBL316161 | — | — | 1 | 7.47 |
| CHEMBL88504 | — | — | 1 | 7.25 |
| CHEMBL88297 | — | — | 1 | 7.21 |
| CHEMBL26922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87195 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL90053 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL316050 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL87348 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL315684 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL89014 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL86648 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL87105 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL88994 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL88157 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL88997 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL316161 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL88504 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL88297 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL26922 | — | Ki | > | 300.0 | nM | - |