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Assay Detail

CHEMBL803397

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Retinoic acid receptor gamma (CHEMBL2003)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
Boehm MF, Zhang L, Badea BA, White SK, Mais DE, Berger E, Suto CM, Goldman ME, Heyman RA.
J Med Chem (1994) 37 : 2930 -2941
PubMed 8071941 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 20 6.05 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96184 1 6.05
CHEMBL328419 1 -
CHEMBL101302 1 -
CHEMBL1023 BEXAROTENE 4.0 1 -
CHEMBL102039 1 -
CHEMBL101666 1 -
CHEMBL419166 1 -
CHEMBL97910 1 -
CHEMBL98142 1 -
CHEMBL99325 1 -
CHEMBL318916 1 -
CHEMBL100986 1 -
CHEMBL101609 1 -
CHEMBL100623 1 -
CHEMBL101212 1 -
CHEMBL330593 1 -
CHEMBL101308 1 -
CHEMBL98172 1 -
CHEMBL101661 1 -
CHEMBL101712 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96184 Kd = 887.0 nM 6.05
CHEMBL328419 Kd > 1000.0 nM -
CHEMBL101302 Kd > 1000.0 nM -
CHEMBL1023 BEXAROTENE Kd > 1000.0 nM -
CHEMBL102039 Kd > 1000.0 nM -
CHEMBL101666 Kd > 1000.0 nM -
CHEMBL419166 Kd > 1000.0 nM -
CHEMBL97910 Kd > 1000.0 nM -
CHEMBL98142 Kd > 1000.0 nM -
CHEMBL99325 Kd > 1000.0 nM -
CHEMBL318916 Kd > 1000.0 nM -
CHEMBL100986 Kd > 1000.0 nM -
CHEMBL101609 Kd > 1000.0 nM -
CHEMBL100623 Kd > 1000.0 nM -
CHEMBL101212 Kd > 1000.0 nM -
CHEMBL330593 Kd > 1000.0 nM -
CHEMBL101308 Kd > 1000.0 nM -
CHEMBL98172 Kd > 1000.0 nM -
CHEMBL101661 Kd > 1000.0 nM -
CHEMBL101712 Kd > 1000.0 nM -