Compound Detail
CHEMBL100623
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Basic Information
| ChEMBL ID | CHEMBL100623 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RJKMEUBHGGZRDO-UHFFFAOYSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
362.5
MW (Da)
6.36
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.69
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.94
Kd 3 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha CHEMBL2061 | Kd | 7.51 | 7.51 | 31.0 | 1 |
| Retinoic acid receptor RXR-beta CHEMBL4047 | Kd | 7.36 | 7.36 | 44.0 | 1 |
| Retinoic acid receptor RXR-gamma CHEMBL4402 | Kd | 7.23 | 7.23 | 59.0 | 1 |
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 6.94 | 6.94 | 115.0 | 1 |
| Retinoic acid receptor RXR-gamma CHEMBL4402 | EC50 | 6.87 | 6.87 | 136.0 | 1 |
| Retinoic acid receptor RXR-beta CHEMBL4047 | EC50 | 6.84 | 6.84 | 145.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | Kd | = | 31.0 | nM | 7.51 | Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RX... | 8071941 |
| Retinoic acid receptor RXR-beta | Kd | = | 44.0 | nM | 7.36 | Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RX... | 8071941 |
| Retinoic acid receptor RXR-gamma | Kd | = | 59.0 | nM | 7.23 | Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RX... | 8071941 |
| Retinoic acid receptor RXR-alpha | EC50 | = | 115.0 | nM | 6.94 | Effective concentration against retinoid receptor isoform (RXR alpha) expressed ... | 8071941 |
| Retinoic acid receptor RXR-gamma | EC50 | = | 136.0 | nM | 6.87 | Effective concentration against retinoid receptor isoform (RXR gamma) expressed ... | 8071941 |
| Retinoic acid receptor RXR-beta | EC50 | = | 145.0 | nM | 6.84 | Effective concentration against retinoid receptor isoform (RXR beta) expressed i... | 8071941 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor alpha | 2 |
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor beta | 2 |
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor gamma | 2 |
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor RXR-alpha | 2 |
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor RXR-beta | 2 |
| 8071941 | 10.1021/jm00044a014 | Retinoic acid receptor RXR-gamma | 2 |
Data from ChEMBL 36 via Core Engine