Assay Detail
Functional
CHEMBL803490
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Inhibition of after-hyperpolarization (AHP) in cultured rat sympathetic neurons
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, molecular modeling, and K+ channel-blocking activity of dequalinium analogues having semirigid linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.30 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6361 | — | — | 1 | 6.72 |
| CHEMBL135904 | — | — | 1 | 6.70 |
| CHEMBL334348 | — | — | 1 | 6.70 |
| CHEMBL6354 | — | — | 1 | 6.54 |
| CHEMBL341203 | — | — | 1 | 6.51 |
| CHEMBL133311 | — | — | 1 | 6.44 |
| CHEMBL441835 | — | — | 1 | 6.43 |
| CHEMBL269729 | — | — | 1 | 6.42 |
| CHEMBL429017 | — | — | 1 | 6.39 |
| CHEMBL6315 | — | — | 1 | 6.35 |
| CHEMBL135913 | — | — | 1 | 6.31 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.19 |
| CHEMBL422094 | — | — | 1 | 6.10 |
| CHEMBL442697 | — | — | 1 | 6.03 |
| CHEMBL335018 | — | — | 1 | 6.00 |
| CHEMBL135990 | — | — | 1 | 5.72 |
| CHEMBL135862 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6361 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL135904 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL334348 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6354 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL341203 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL133311 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL441835 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL269729 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL429017 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL6315 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL135913 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL422094 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL442697 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL335018 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL135990 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL135862 | — | IC50 | = | 2800.0 | nM | 5.55 |