Assay Detail
Functional
CHEMBL803551
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In vitro antagonist activity by its ability to inhibit glutamate-induced accumulation of [45Ca2+]- in cultured rat cortical neurons.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.81 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22304 | — | — | 1 | 5.62 |
| CHEMBL29244 | — | — | 1 | 5.28 |
| CHEMBL28862 | — | — | 1 | 5.21 |
| CHEMBL29255 | — | — | 1 | 4.78 |
| CHEMBL274440 | AP-7 | — | 1 | 4.52 |
| CHEMBL3349424 | — | — | 1 | 4.44 |
| CHEMBL28609 | — | — | 1 | 4.40 |
| CHEMBL27735 | — | — | 1 | 4.23 |
| CHEMBL29193 | — | — | 1 | - |
| CHEMBL443231 | — | — | 1 | - |
| CHEMBL284880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22304 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL29244 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL28862 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL29255 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL274440 | AP-7 | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3349424 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL28609 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL27735 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL29193 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL443231 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL284880 | — | IC50 | = | 137000.0 | nM | - |