Assay Detail
Functional
CHEMBL803797
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Tested for the ability to inhibit growth in vitro against S180
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CCRF S-180 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.29 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136010 | — | — | 1 | 8.72 |
| CHEMBL337051 | — | — | 1 | 8.59 |
| CHEMBL341401 | — | — | 1 | 8.42 |
| CHEMBL132142 | — | — | 1 | 8.41 |
| CHEMBL134817 | — | — | 1 | 8.41 |
| CHEMBL335716 | — | — | 1 | 8.23 |
| CHEMBL132431 | — | — | 1 | 8.03 |
| CHEMBL134110 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136010 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL337051 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL341401 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL132142 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL134817 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL335716 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL132431 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL134110 | — | IC50 | = | 33.0 | nM | 7.48 |