Assay Detail
Binding
CHEMBL804009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intrinsic affinity towards serotonin receptor from rat frontal cortex by displacement of [3H]spiperone.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bioactive conformation of 1-arylpiperazines at central serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.21 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351530 | — | — | 1 | 6.87 |
| CHEMBL274866 | — | — | 1 | 6.53 |
| CHEMBL269521 | MK-212 | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351530 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL274866 | — | Ki | = | 298.0 | nM | 6.53 |
| CHEMBL269521 | MK-212 | Ki | = | 6000.0 | nM | 5.22 |