Assay Detail
Binding
CHEMBL804010
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In vitro inhibitory activity against serotonin receptor from rat frontal cortex using [3H]spiperone as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | 2.0 | 1 | 7.58 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 6.85 |
| CHEMBL330849 | — | — | 1 | 6.14 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 5.35 |
| CHEMBL2218861 | QUINAGOLIDE | 4.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL330849 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2218861 | QUINAGOLIDE | IC50 | = | 5100.0 | nM | 5.29 |