Assay Detail
Binding
CHEMBL804348
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Activity determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.44 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45769 | — | — | 1 | 6.26 |
| CHEMBL297437 | — | — | 1 | 5.98 |
| CHEMBL609353 | — | — | 1 | 5.00 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45769 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL297437 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL609353 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1090 | VIDARABINE | Ki | = | 30000.0 | nM | 4.52 |