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Assay Detail

CHEMBL804350

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory effect against L929 Cell S-adenosyl-L-homocysteine hydrolase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosylhomocysteinase (CHEMBL2389)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents.
Shuto S, Obara T, Toriya M, Hosoya M, Snoeck R, Andrei G, Balzarini J, De Clercq E.
J Med Chem (1992) 35 : 324 -331
PubMed 1732550 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 6.05 7.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL327105 1 7.07
CHEMBL299135 1 6.82
CHEMBL113259 1 4.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL327105 Ki = 86.0 nM 7.07
CHEMBL299135 Ki = 150.0 nM 6.82
CHEMBL113259 Ki = 55700.0 nM 4.25