Assay Detail
Binding
CHEMBL804369
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Beta-Lactamase inhibitory activity against representative class A (TEM-1) serine enzyme
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.26 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 6.91 |
| CHEMBL416561 | — | — | 1 | 6.19 |
| CHEMBL25766 | — | — | 1 | 5.17 |
| CHEMBL24878 | — | — | 1 | 4.84 |
| CHEMBL24235 | — | — | 1 | 4.29 |
| CHEMBL26275 | — | — | 1 | 4.16 |
| CHEMBL25644 | — | — | 1 | - |
| CHEMBL24275 | — | — | 1 | - |
| CHEMBL277857 | — | — | 1 | - |
| CHEMBL277225 | — | — | 1 | - |
| CHEMBL25613 | — | — | 1 | - |
| CHEMBL24351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL416561 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL25766 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL24878 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL24235 | — | IC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL26275 | — | IC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL25644 | — | IC50 | = | 601000.0 | nM | - |
| CHEMBL24275 | — | IC50 | = | 988000.0 | nM | - |
| CHEMBL277857 | — | IC50 | = | 275000.0 | nM | - |
| CHEMBL277225 | — | IC50 | = | 648000.0 | nM | - |
| CHEMBL25613 | — | IC50 | = | 752000.0 | nM | - |
| CHEMBL24351 | — | IC50 | > | 1000000.0 | nM | - |