Assay Detail
Binding
CHEMBL804526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.77 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332257 | — | — | 1 | 8.10 |
| CHEMBL118603 | — | — | 1 | 7.80 |
| CHEMBL331513 | — | — | 1 | 7.72 |
| CHEMBL117331 | — | — | 1 | 7.60 |
| CHEMBL119139 | — | — | 1 | 7.58 |
| CHEMBL331942 | — | — | 1 | 7.55 |
| CHEMBL120306 | — | — | 1 | 7.52 |
| CHEMBL334104 | — | — | 1 | 7.16 |
| CHEMBL119494 | — | — | 1 | 7.07 |
| CHEMBL118682 | — | — | 1 | 7.00 |
| CHEMBL418863 | — | — | 1 | 6.84 |
| CHEMBL118626 | — | — | 1 | 6.49 |
| CHEMBL119103 | — | — | 1 | 6.29 |
| CHEMBL3037819 | — | — | 1 | 5.84 |
| CHEMBL330800 | — | — | 1 | 5.84 |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 1 | 4.51 |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | 4.25 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332257 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL118603 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL331513 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL117331 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL119139 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL331942 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL120306 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL334104 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL119494 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL118682 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL418863 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL118626 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL119103 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL3037819 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL330800 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL741 | LAMOTRIGINE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL79 | LIDOCAINE | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL108 | CARBAMAZEPINE | IC50 | = | 167000.0 | nM | - |