Assay Detail
Binding
CHEMBL804528
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Inhibition of [3H]batrachotoxin binding to rat brain sodium channel
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.18 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85054 | — | — | 1 | 5.96 |
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | 5.89 |
| CHEMBL84167 | — | — | 1 | 5.85 |
| CHEMBL85962 | — | — | 1 | 5.11 |
| CHEMBL48582 | SAFINAMIDE MESYLATE | 4.0 | 1 | 5.09 |
| CHEMBL82327 | — | — | 1 | 5.07 |
| CHEMBL315738 | — | — | 1 | 4.95 |
| CHEMBL85371 | — | — | 1 | 4.88 |
| CHEMBL83621 | — | — | 1 | 4.86 |
| CHEMBL85899 | — | — | 1 | 4.75 |
| CHEMBL311029 | — | — | 1 | 4.58 |
| CHEMBL315093 | — | — | 1 | - |
| CHEMBL419673 | — | — | 1 | - |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85054 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL52440 | DEXTROMETHORPHAN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL84167 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL85962 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL48582 | SAFINAMIDE MESYLATE | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL82327 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL315738 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL85371 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL83621 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL85899 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL311029 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL315093 | — | IC50 | = | 145800.0 | nM | - |
| CHEMBL419673 | — | IC50 | = | 150800.0 | nM | - |
| CHEMBL741 | LAMOTRIGINE | IC50 | = | 185900.0 | nM | - |