Assay Detail
Binding
CHEMBL804533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]batrachotoxin from rat brain sodium channel
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.60 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744044 | — | — | 1 | 6.39 |
| CHEMBL320068 | — | — | 1 | 5.61 |
| CHEMBL51433 | — | — | 1 | 5.43 |
| CHEMBL106186 | — | — | 1 | 5.32 |
| CHEMBL107084 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744044 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL320068 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL51433 | — | Ki | = | 3680.0 | nM | 5.43 |
| CHEMBL106186 | — | Ki | = | 4810.0 | nM | 5.32 |
| CHEMBL107084 | — | Ki | = | 5380.0 | nM | 5.27 |