Assay Detail
Binding
CHEMBL804534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.22 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 7.28 |
| CHEMBL92977 | — | — | 1 | 7.19 |
| CHEMBL92018 | — | — | 1 | 7.14 |
| CHEMBL92870 | LIDOFLAZINE | 2.0 | 1 | 7.11 |
| CHEMBL327859 | — | — | 1 | 6.96 |
| CHEMBL92071 | — | — | 1 | 6.89 |
| CHEMBL93436 | — | — | 1 | 6.72 |
| CHEMBL329245 | — | — | 1 | 6.62 |
| CHEMBL282833 | — | — | 1 | 6.58 |
| CHEMBL330049 | — | — | 1 | 6.42 |
| CHEMBL93634 | — | — | 1 | 6.39 |
| CHEMBL92918 | — | — | 1 | 6.32 |
| CHEMBL93106 | — | — | 1 | 6.00 |
| CHEMBL313859 | — | — | 1 | 6.00 |
| CHEMBL93838 | — | — | 1 | 5.70 |
| CHEMBL91288 | — | — | 1 | 5.64 |
| CHEMBL93271 | — | — | 1 | 5.16 |
| CHEMBL94137 | — | — | 1 | 4.82 |
| CHEMBL91929 | — | — | 1 | 4.68 |
| CHEMBL93065 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL92977 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL92018 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL92870 | LIDOFLAZINE | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL327859 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL92071 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL93436 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL329245 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL282833 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL330049 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL93634 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL92918 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL93106 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL313859 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL93838 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL91288 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL93271 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL94137 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL91929 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL93065 | — | Ki | = | 21000.0 | nM | 4.68 |