Assay Detail
Functional
CHEMBL804763
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Antagonism of in vitro SRIF inhibition of GH release from rat pituitary cells in culture
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Pituitary gland cell |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.88 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311098 | — | — | 1 | 9.28 |
| CHEMBL2369754 | — | — | 1 | 8.60 |
| CHEMBL2369749 | — | — | 1 | 8.59 |
| CHEMBL2369750 | — | — | 1 | 8.11 |
| CHEMBL2369735 | — | — | 1 | 7.94 |
| CHEMBL2369758 | — | — | 1 | 7.02 |
| CHEMBL2369760 | — | — | 1 | 6.99 |
| CHEMBL2369757 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311098 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL2369754 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2369749 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2369750 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL2369735 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL2369758 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2369760 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2369757 | — | IC50 | = | 287.0 | nM | 6.54 |