Assay Detail
Binding
CHEMBL804937
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Inhibition of binding to murine Retinoic acid receptor RAR gamma
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.11 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.40 |
| CHEMBL46398 | — | — | 1 | 8.00 |
| CHEMBL75548 | — | — | 1 | 7.22 |
| CHEMBL2111557 | — | — | 1 | 6.15 |
| CHEMBL72988 | — | — | 1 | 5.80 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL46398 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL75548 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2111557 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL72988 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL547 | ISOTRETINOIN | IC50 | > | 1000.0 | nM | - |