Assay Detail
Binding
CHEMBL804938
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Inhibition of binding to retinoid A receptor RAR gamma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.41 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.40 |
| CHEMBL46398 | — | — | 1 | 8.00 |
| CHEMBL46397 | — | — | 1 | 7.26 |
| CHEMBL44478 | — | — | 1 | 7.22 |
| CHEMBL44582 | — | — | 1 | 6.15 |
| CHEMBL44979 | — | — | 1 | - |
| CHEMBL296193 | — | — | 1 | - |
| CHEMBL43833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL46398 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL46397 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL44478 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL44582 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL44979 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL296193 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL43833 | — | IC50 | > | 1000.0 | nM | - |