Assay Detail
Binding
CHEMBL805023
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Transactivation potency for Retinoic acid receptor gamma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 8.70 |
| CHEMBL80271 | — | — | 1 | 8.52 |
| CHEMBL76313 | — | — | 1 | 8.40 |
| CHEMBL311269 | — | — | 1 | 8.22 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.00 |
| CHEMBL430616 | — | — | 1 | 7.70 |
| CHEMBL75741 | — | — | 1 | 7.27 |
| CHEMBL80820 | — | — | 1 | 6.89 |
| CHEMBL306999 | — | — | 1 | 6.70 |
| CHEMBL308967 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL80271 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL76313 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL311269 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL38 | TRETINOIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL430616 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL75741 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL80820 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL306999 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308967 | — | EC50 | = | 260.0 | nM | 6.58 |