Assay Detail
Functional
CHEMBL805028
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In vitro antitumor activity against melanoma SK-MEL-2 tumor cell lines
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.92 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334648 | RORIDIN A | — | 1 | 8.52 |
| CHEMBL136985 | VERRUCARIN A | — | 1 | 8.10 |
| CHEMBL136268 | RORIDIN L | — | 1 | 7.62 |
| CHEMBL136396 | VERRUCARRIN M | — | 1 | 7.43 |
| CHEMBL435984 | RORIDIN M | — | 1 | 6.58 |
| CHEMBL136053 | TRICHOVERRIN A | — | 1 | 5.12 |
| CHEMBL136186 | TRICHOVERRIN B | — | 1 | 5.05 |
| CHEMBL335838 | — | — | 1 | - |
| CHEMBL433680 | ANGUIDIN | — | 1 | - |
| CHEMBL341800 | (6'R,13'S) ISORORIDIN A | — | 1 | - |
| CHEMBL2368056 | Miophytocen C | — | 1 | - |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334648 | RORIDIN A | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL136985 | VERRUCARIN A | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL136268 | RORIDIN L | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL136396 | VERRUCARRIN M | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL435984 | RORIDIN M | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL136053 | TRICHOVERRIN A | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL136186 | TRICHOVERRIN B | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL335838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL433680 | ANGUIDIN | IC50 | < | 1.0 | nM | - |
| CHEMBL341800 | (6'R,13'S) ISORORIDIN A | IC50 | > | 10000.0 | nM | - |
| CHEMBL2368056 | Miophytocen C | IC50 | > | 10000.0 | nM | - |
| CHEMBL335603 | 13`-ACETYLTRICHOVERRIN B | IC50 | > | 10000.0 | nM | - |