Assay Detail
Binding
CHEMBL805109
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Inhibition of T cell protein tyrosine phosphatase (TC-PTP) at pH 7.0
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.81 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139393 | — | — | 1 | 5.03 |
| CHEMBL138461 | — | — | 1 | 5.00 |
| CHEMBL139074 | — | — | 1 | 4.96 |
| CHEMBL341947 | — | — | 1 | 4.92 |
| CHEMBL139196 | — | — | 1 | 4.92 |
| CHEMBL424652 | — | — | 1 | 4.92 |
| CHEMBL342603 | — | — | 1 | 4.89 |
| CHEMBL344368 | — | — | 1 | 4.77 |
| CHEMBL136867 | — | — | 1 | 4.72 |
| CHEMBL136044 | — | — | 1 | 4.66 |
| CHEMBL138951 | — | — | 1 | 4.62 |
| CHEMBL138277 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139393 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL138461 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL139074 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL341947 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL139196 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL424652 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL342603 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL344368 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL136867 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL136044 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL138951 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL138277 | — | Ki | = | 48000.0 | nM | 4.32 |