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Assay Detail

CHEMBL805165

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for [Ca2+] release in 45 [Ca2+] -preloaded SH-SY5Y cells using saponin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SH-SY5Y
Confidence 1 — Organism
Curated By Autocuration

Publication

Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.
Kozikowski AP, Ognyanov VI, Chen C, Fauq AH, Safrany ST, Wilcox RA, Nahorski SR.
J Med Chem (1993) 36 : 3035 -3038
PubMed 8411022 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.94 7.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279107 INS(1,4,5)P3 1 7.28
CHEMBL1160800 1 6.81
CHEMBL1160797 1 6.73
CHEMBL1160798 1 -
CHEMBL2092922 1 -
CHEMBL1160801 1 -
CHEMBL1160811 1 -
CHEMBL2092837 1 -
CHEMBL1160802 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279107 INS(1,4,5)P3 EC50 = 52.1 nM 7.28
CHEMBL1160800 EC50 = 155.7 nM 6.81
CHEMBL1160797 EC50 = 185.7 nM 6.73
CHEMBL1160798 EC50 > 100000.0 nM -
CHEMBL2092922 EC50 > 100000.0 nM -
CHEMBL1160801 EC50 > 10000.0 nM -
CHEMBL1160811 EC50 > 100000.0 nM -
CHEMBL2092837 EC50 > 100000.0 nM -
CHEMBL1160802 EC50 > 100000.0 nM -