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Assay Detail

CHEMBL805252

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-proliferative activity was evaluated by its ability to inhibit proliferation of SW480 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW480
Confidence 1 — Organism
Curated By Intermediate

Target

SW480 (CHEMBL612544)
Type CELL-LINE
Organism Homo sapiens

Publication

New indene-derivatives with anti-proliferative properties.
Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V, Winde G, Möröy T, Müller O.
Bioorg Med Chem Lett (2002) 12 : 709 -713
PubMed 11844707 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.13 4.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL352898 1 4.16
CHEMBL351496 1 4.10
CHEMBL18797 SULINDAC SULFIDE -1.0 1 -
CHEMBL163333 1 -
CHEMBL353128 1 -
CHEMBL15770 SULINDAC 4.0 1 -
CHEMBL163404 1 -
CHEMBL434291 1 -
CHEMBL159846 1 -
CHEMBL163514 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL352898 IC50 = 70000.0 nM 4.16
CHEMBL351496 IC50 = 80000.0 nM 4.10
CHEMBL18797 SULINDAC SULFIDE IC50 = 200000.0 nM -
CHEMBL163333 IC50 = 360000.0 nM -
CHEMBL353128 IC50 = 400000.0 nM -
CHEMBL15770 SULINDAC IC50 = 800000.0 nM -
CHEMBL163404 IC50 = 850000.0 nM -
CHEMBL434291 IC50 = 310000.0 nM -
CHEMBL159846 IC50 = 380000.0 nM -
CHEMBL163514 IC50 = 320000.0 nM -