Assay Detail
Binding
CHEMBL805362
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In vitro inhibition of Src protein tyrosine kinase using the Scintillation proximity kinase assay.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318996 | — | — | 1 | 8.40 |
| CHEMBL3706663 | — | — | 1 | 7.70 |
| CHEMBL105056 | — | — | 1 | 7.40 |
| CHEMBL102946 | — | — | 1 | 7.40 |
| CHEMBL104215 | — | — | 1 | 7.22 |
| CHEMBL321779 | — | — | 1 | 6.92 |
| CHEMBL105436 | — | — | 1 | 6.80 |
| CHEMBL104857 | — | — | 1 | 6.60 |
| CHEMBL421025 | — | — | 1 | 6.51 |
| CHEMBL3706661 | — | — | 1 | 6.50 |
| CHEMBL321116 | — | — | 1 | 6.44 |
| CHEMBL3706662 | — | — | 1 | 6.40 |
| CHEMBL421405 | — | — | 1 | 6.17 |
| CHEMBL102183 | — | — | 1 | 6.16 |
| CHEMBL321569 | — | — | 1 | 6.06 |
| CHEMBL320417 | — | — | 1 | 5.94 |
| CHEMBL317693 | — | — | 1 | 5.82 |
| CHEMBL3706664 | — | — | 1 | 5.80 |
| CHEMBL105516 | — | — | 1 | 5.60 |
| CHEMBL105005 | — | — | 1 | 5.40 |
| CHEMBL104077 | — | — | 1 | 4.72 |
| CHEMBL101795 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318996 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3706663 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL105056 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL102946 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL104215 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL321779 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL105436 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL104857 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL421025 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3706661 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL321116 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3706662 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL421405 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL102183 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL321569 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL320417 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL317693 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3706664 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL105516 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL105005 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL104077 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL101795 | — | IC50 | = | 40000.0 | nM | 4.40 |