Assay Detail
Functional
CHEMBL805455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth in human ovarian carcinoma cell line(SKOV-3) using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.93 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | 2.0 | 1 | 8.04 |
| CHEMBL279754 | DSB-120 | — | 1 | 6.13 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 4.98 |
| CHEMBL164587 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL279754 | DSB-120 | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL164587 | — | IC50 | = | 28000.0 | nM | 4.55 |