Assay Detail
Functional
CHEMBL805759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition against human SISO cell lines
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SISO |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.95 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.82 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.70 |
| CHEMBL117076 | — | — | 1 | 6.57 |
| CHEMBL440896 | — | — | 1 | 6.51 |
| CHEMBL116696 | — | — | 1 | 6.43 |
| CHEMBL117966 | — | — | 1 | 6.39 |
| CHEMBL430890 | — | — | 1 | 6.29 |
| CHEMBL323906 | — | — | 1 | 6.27 |
| CHEMBL113922 | — | — | 1 | 6.25 |
| CHEMBL331583 | — | — | 1 | 6.11 |
| CHEMBL113815 | — | — | 1 | 5.92 |
| CHEMBL117195 | — | — | 1 | 5.49 |
| CHEMBL117536 | — | — | 1 | 5.48 |
| CHEMBL118079 | — | — | 1 | 4.85 |
| CHEMBL116569 | — | — | 1 | 4.59 |
| CHEMBL114935 | — | — | 1 | 4.51 |
| CHEMBL334049 | — | — | 1 | - |
| CHEMBL331840 | — | — | 1 | - |
| CHEMBL118009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL117076 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL440896 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL116696 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL117966 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL430890 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL323906 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL113922 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL331583 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL113815 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL117195 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL117536 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL118079 | — | IC50 | = | 14030.0 | nM | 4.85 |
| CHEMBL116569 | — | IC50 | = | 25860.0 | nM | 4.59 |
| CHEMBL114935 | — | IC50 | = | 30890.0 | nM | 4.51 |
| CHEMBL334049 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL331840 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL118009 | — | IC50 | > | 20000.0 | nM | - |