Assay Detail
Functional
CHEMBL805827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against SF-162 (M) Macrophage tropic virus that utilizes the CCR5 was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | sf-162 macrophage tropic virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.55 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337301 | — | — | 1 | 8.46 |
| CHEMBL336293 | — | — | 1 | 6.64 |
| CHEMBL135339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337301 | — | EC50 | = | 3.46 | nM | 8.46 |
| CHEMBL336293 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL135339 | — | EC50 | - | nM | - |