Assay Detail
Binding
CHEMBL805837
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Ability to block 5-HT4 receptor mediated effect of 5-HT was assessed in the guinea-pig distal colon longitudinal muscle myenteric plexus preparation (LMMP)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
5-HT4receptor antagonists : oxazolo, oxazino and oxazepino[3,2-a]indole derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.96 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358119 | — | — | 1 | 10.60 |
| CHEMBL68131 | — | — | 1 | 10.10 |
| CHEMBL145075 | — | — | 1 | 10.00 |
| CHEMBL143862 | — | — | 1 | 9.80 |
| CHEMBL143426 | — | — | 1 | 9.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358119 | — | IC50 | = | 0.02512 | nM | 10.60 |
| CHEMBL68131 | — | IC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL145075 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL143862 | — | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL143426 | — | IC50 | = | 0.5012 | nM | 9.30 |