Assay Detail
Binding
CHEMBL805838
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Compound was tested for binding affinity against 5-HT4 receptor in guinea pig striata using [3H]GR-113808 as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and preliminary pharmacological evaluation of 2-benzyloxy substituted aryl ketones as 5-HT4 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.43 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68131 | — | — | 1 | 10.89 |
| CHEMBL82976 | — | — | 1 | 9.47 |
| CHEMBL84294 | — | — | 1 | 9.33 |
| CHEMBL310667 | — | — | 1 | 9.32 |
| CHEMBL66114 | — | — | 1 | 9.13 |
| CHEMBL83755 | — | — | 1 | 9.09 |
| CHEMBL80026 | — | — | 1 | 8.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68131 | — | Ki | = | 0.01288 | nM | 10.89 |
| CHEMBL82976 | — | Ki | = | 0.3388 | nM | 9.47 |
| CHEMBL84294 | — | Ki | = | 0.4677 | nM | 9.33 |
| CHEMBL310667 | — | Ki | = | 0.4786 | nM | 9.32 |
| CHEMBL66114 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL83755 | — | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL80026 | — | Ki | = | 1.778 | nM | 8.75 |