Assay Detail
Binding
CHEMBL805839
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Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radioligand [125I]SB 207710 to piglet hippocampal membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT4receptor antagonists : oxazolo, oxazino and oxazepino[3,2-a]indole derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.70 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358119 | — | — | 1 | 10.20 |
| CHEMBL145075 | — | — | 1 | 10.10 |
| CHEMBL68131 | — | — | 1 | 9.90 |
| CHEMBL143862 | — | — | 1 | 9.70 |
| CHEMBL143426 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358119 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL145075 | — | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL68131 | — | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL143862 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL143426 | — | Ki | = | 2.512 | nM | 8.60 |