Assay Detail
Binding
CHEMBL806180
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Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.49 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119349 | — | — | 1 | 9.04 |
| CHEMBL117031 | — | — | 1 | 8.70 |
| CHEMBL118860 | — | — | 2 | 8.57 |
| CHEMBL117973 | — | — | 1 | 8.57 |
| CHEMBL118265 | — | — | 1 | 8.55 |
| CHEMBL334213 | — | — | 1 | 8.44 |
| CHEMBL325193 | — | — | 1 | 8.37 |
| CHEMBL117130 | — | — | 1 | 8.20 |
| CHEMBL119760 | — | — | 1 | 8.00 |
| CHEMBL119562 | — | — | 1 | 7.89 |
| CHEMBL119110 | — | — | 1 | 7.85 |
| CHEMBL119233 | — | — | 1 | 7.85 |
| CHEMBL115738 | — | — | 1 | 7.82 |
| CHEMBL115713 | — | — | 1 | 7.75 |
| CHEMBL421234 | — | — | 1 | 7.40 |
| CHEMBL334144 | — | — | 1 | 7.33 |
| CHEMBL117569 | — | — | 1 | 6.89 |
| CHEMBL432809 | — | — | 1 | 6.77 |
| CHEMBL116140 | — | — | 1 | 6.77 |
| CHEMBL325198 | — | — | 1 | 6.55 |
| CHEMBL424254 | — | — | 1 | 6.46 |
| CHEMBL118068 | — | — | 1 | 6.43 |
| CHEMBL119516 | — | — | 1 | 6.41 |
| CHEMBL119257 | — | — | 1 | 6.00 |
| CHEMBL1160958 | — | — | 1 | 6.00 |
| CHEMBL432632 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119349 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL117031 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL118860 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL117973 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL118265 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL334213 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL325193 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL117130 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL119760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL119562 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL119110 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL119233 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL115738 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL115713 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL118860 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL421234 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL334144 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL117569 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL432809 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL116140 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL325198 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL424254 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL118068 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL119516 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL119257 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1160958 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL432632 | — | IC50 | = | 1200.0 | nM | 5.92 |