Assay Detail
Binding
CHEMBL806183
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Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.09 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 10.40 |
| CHEMBL432067 | — | — | 1 | 9.15 |
| CHEMBL114606 | — | — | 1 | 8.20 |
| CHEMBL115554 | — | — | 1 | 7.75 |
| CHEMBL113344 | — | — | 1 | 7.21 |
| CHEMBL112655 | — | — | 1 | 7.17 |
| CHEMBL115713 | — | — | 1 | 7.07 |
| CHEMBL325198 | — | — | 1 | 6.55 |
| CHEMBL114976 | — | — | 1 | 6.50 |
| CHEMBL115714 | — | — | 1 | 6.50 |
| CHEMBL114584 | — | — | 1 | 6.29 |
| CHEMBL91283 | — | — | 1 | 6.14 |
| CHEMBL325050 | — | — | 1 | 5.18 |
| CHEMBL115131 | — | — | 1 | 5.12 |
| CHEMBL326346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL432067 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL114606 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL115554 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL113344 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL112655 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL115713 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL325198 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL114976 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL115714 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL114584 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL91283 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL325050 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL115131 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL326346 | — | IC50 | > | 10000.0 | nM | - |