Assay Detail
Functional
CHEMBL806236
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Compound was evaluated for its ability to inhibit IL-6 production in SW1353 cells treated with cytokines IL-1 and TNF
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a new class of p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 7.30 |
| CHEMBL41653 | — | — | 1 | 6.09 |
| CHEMBL302379 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL41653 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL302379 | — | IC50 | = | 1200.0 | nM | 5.92 |