Compound Detail
CHEMBL302379
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Basic Information
| ChEMBL ID | CHEMBL302379 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LPEKZMUSADNNSA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
328.2
MW (Da)
4.92
ALogP
3
HBA
2
HBD
67.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| SW1353 CHEMBL614944 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 58.0 | nM | 7.24 | Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 express... | 10999467 |
| SW1353 | IC50 | = | 1200.0 | nM | 5.92 | Compound was evaluated for its ability to inhibit IL-6 production in SW1353 cell... | 10999467 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10999467 | 10.1016/s0960-894x(00)00270-5 | Mitogen-activated protein kinase 14 | 2 |
| 10999467 | 10.1016/s0960-894x(00)00270-5 | SW1353 | 1 |
Data from ChEMBL 36 via Core Engine