Assay Detail
Binding
CHEMBL732963
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Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in Escherichia coli.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a new class of p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62794 | — | — | 1 | 8.70 |
| CHEMBL10 | SB-203580 | — | 1 | 7.70 |
| CHEMBL292482 | — | — | 1 | 7.44 |
| CHEMBL41653 | — | — | 1 | 7.28 |
| CHEMBL302379 | — | — | 1 | 7.24 |
| CHEMBL62788 | — | — | 1 | 7.00 |
| CHEMBL64510 | — | — | 1 | 6.92 |
| CHEMBL304936 | — | — | 1 | 6.92 |
| CHEMBL62008 | — | — | 1 | 6.92 |
| CHEMBL64075 | — | — | 1 | 6.80 |
| CHEMBL59652 | — | — | 1 | 6.72 |
| CHEMBL62946 | — | — | 1 | 6.70 |
| CHEMBL65671 | — | — | 1 | 6.66 |
| CHEMBL61510 | — | — | 1 | 6.58 |
| CHEMBL61628 | — | — | 1 | 6.54 |
| CHEMBL291413 | — | — | 1 | 6.43 |
| CHEMBL62665 | — | — | 1 | 6.15 |
| CHEMBL64644 | — | — | 1 | 6.04 |
| CHEMBL63101 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62794 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL10 | SB-203580 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL292482 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL41653 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL302379 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL62788 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL64510 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL304936 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL62008 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL64075 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL59652 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL62946 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL65671 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL61510 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL61628 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL291413 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL62665 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL64644 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL63101 | — | IC50 | = | 1100.0 | nM | 5.96 |