Assay Detail
Functional
CHEMBL806237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-6 production by SW1353 cells treated with both cytokines IL-1 and TNF-alpha.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.79 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18520 | — | — | 1 | 7.82 |
| CHEMBL18908 | — | — | 1 | 7.80 |
| CHEMBL18103 | — | — | 1 | 7.46 |
| CHEMBL10 | SB-203580 | — | 1 | 7.30 |
| CHEMBL18950 | — | — | 1 | 7.10 |
| CHEMBL278924 | — | — | 1 | 6.51 |
| CHEMBL278719 | — | — | 1 | 6.47 |
| CHEMBL18771 | — | — | 1 | 6.33 |
| CHEMBL279377 | — | — | 1 | 6.04 |
| CHEMBL18764 | — | — | 1 | 5.94 |
| CHEMBL18754 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18520 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL18908 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL18103 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL10 | SB-203580 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL18950 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL278924 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL278719 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL18771 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL279377 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL18764 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL18754 | — | IC50 | = | 1350.0 | nM | 5.87 |