Compound Detail
CHEMBL18520
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Basic Information
| ChEMBL ID | CHEMBL18520 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUQGCASIGSSLDX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
328.4
MW (Da)
3.62
ALogP
2
HBA
4
HBD
86.0
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SW1353 CHEMBL614944 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.17 | 7.17 | 67.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SW1353 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of IL-6 production by SW1353 cells treated with both cytokines IL-1 a... | 11140741 |
| Mitogen-activated protein kinase 14 | IC50 | = | 67.0 | nM | 7.17 | In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from... | 11140741 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11140741 | 10.1016/s0960-894x(00)00574-6 | Mitogen-activated protein kinase 14 | 1 |
| 11140741 | 10.1016/s0960-894x(00)00574-6 | SW1353 | 1 |
| 11140741 | 10.1016/s0960-894x(00)00574-6 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine