Assay Detail
Functional
CHEMBL806243
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Inhibitory concentration required against cell wall synthesis in Staphylococcus aureus (MI246)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.75 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | 6.40 |
| CHEMBL273792 | — | — | 1 | 4.77 |
| CHEMBL280090 | — | — | 1 | 4.44 |
| CHEMBL278929 | — | — | 1 | 4.36 |
| CHEMBL14921 | — | — | 1 | 4.33 |
| CHEMBL416350 | — | — | 1 | 4.18 |
| CHEMBL15724 | — | — | 1 | - |
| CHEMBL278721 | — | — | 1 | - |
| CHEMBL274923 | — | — | 1 | - |
| CHEMBL15723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262777 | VANCOMYCIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL273792 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL280090 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL278929 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL14921 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL416350 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL15724 | — | IC50 | = | 236000.0 | nM | - |
| CHEMBL278721 | — | IC50 | = | 167000.0 | nM | - |
| CHEMBL274923 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL15723 | — | IC50 | = | 135000.0 | nM | - |