Assay Detail
Functional
CHEMBL806422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src-transformed cell proliferation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Src-transformed |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.29 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.00 |
| CHEMBL290921 | — | — | 1 | 7.00 |
| CHEMBL338413 | — | — | 1 | 6.72 |
| CHEMBL42136 | — | — | 1 | 6.66 |
| CHEMBL41465 | — | — | 1 | 6.64 |
| CHEMBL127771 | — | — | 1 | 6.48 |
| CHEMBL124333 | — | — | 1 | 6.43 |
| CHEMBL122744 | — | — | 1 | 6.00 |
| CHEMBL436362 | — | — | 1 | 5.92 |
| CHEMBL123733 | — | — | 1 | 5.92 |
| CHEMBL419428 | — | — | 1 | 5.85 |
| CHEMBL43577 | — | — | 1 | 5.85 |
| CHEMBL127633 | — | — | 1 | 5.85 |
| CHEMBL440847 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL290921 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL338413 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL42136 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL41465 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL127771 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL124333 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL122744 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL436362 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL123733 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL419428 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL43577 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL127633 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL440847 | — | IC50 | = | 1600.0 | nM | 5.80 |