Compound Detail
CHEMBL436362
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL436362 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VOUVVBUKNLBXGS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
521.6
MW (Da)
3.90
ALogP
10
HBA
1
HBD
101.3
PSA (Ų)
0.37
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 8.29 | 8.29 | 5.1 | 1 |
| Src-transformed CHEMBL614302 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 5.1 | nM | 8.29 | Inhibition of Src protein tyrosine kinase | 14552782 |
| Src-transformed | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of Src-transformed cell proliferation | 14552782 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14552782 | 10.1016/j.bmcl.2003.07.001 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 14552782 | 10.1016/j.bmcl.2003.07.001 | Src-transformed | 1 |
Data from ChEMBL 36 via Core Engine