Assay Detail
Binding
CHEMBL806435
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Inhibition of Src protein tyrosine kinase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.34 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.92 |
| CHEMBL290921 | — | — | 1 | 8.85 |
| CHEMBL124333 | — | — | 1 | 8.82 |
| CHEMBL42136 | — | — | 1 | 8.70 |
| CHEMBL41465 | — | — | 1 | 8.62 |
| CHEMBL338413 | — | — | 1 | 8.55 |
| CHEMBL127633 | — | — | 1 | 8.33 |
| CHEMBL436362 | — | — | 1 | 8.29 |
| CHEMBL43577 | — | — | 1 | 8.18 |
| CHEMBL440847 | — | — | 1 | 8.08 |
| CHEMBL122744 | — | — | 1 | 8.06 |
| CHEMBL123733 | — | — | 1 | 7.92 |
| CHEMBL127771 | — | — | 1 | 7.85 |
| CHEMBL419428 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL290921 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL124333 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL42136 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL41465 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL338413 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL127633 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL436362 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL43577 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL440847 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL122744 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL123733 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL127771 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL419428 | — | IC50 | = | 25.0 | nM | 7.60 |