Assay Detail
Binding
CHEMBL806514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro transcriptional activation in CV-1 cells expressing RXR-alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Retinoic acid receptor RXR-alpha (CHEMBL4431) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.23 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133176 | — | — | 1 | 8.35 |
| CHEMBL42314 | — | — | 1 | 8.10 |
| CHEMBL288436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133176 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL42314 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL288436 | — | IC50 | = | - | nM | - |