Assay Detail
Binding
CHEMBL806515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determined
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Retinoic acid receptor RXR-alpha (CHEMBL4431) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.83 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337719 | — | — | 1 | 8.64 |
| CHEMBL336086 | — | — | 1 | 8.48 |
| CHEMBL340074 | — | — | 1 | 8.29 |
| CHEMBL131561 | — | — | 1 | 8.17 |
| CHEMBL335762 | — | — | 1 | 8.06 |
| CHEMBL339298 | — | — | 1 | 7.99 |
| CHEMBL132488 | — | — | 1 | 7.98 |
| CHEMBL340555 | — | — | 1 | 7.94 |
| CHEMBL335751 | — | — | 1 | 7.94 |
| CHEMBL129887 | — | — | 1 | 7.81 |
| CHEMBL129976 | — | — | 1 | 7.33 |
| CHEMBL445634 | — | — | 1 | 7.30 |
| CHEMBL130230 | — | — | 1 | 7.10 |
| CHEMBL130577 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337719 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL336086 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL340074 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL131561 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL335762 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL339298 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL132488 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL340555 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL335751 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL129887 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL129976 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL445634 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL130230 | — | IC50 | = | 79.9 | nM | 7.10 |
| CHEMBL130577 | — | IC50 | = | 271.2 | nM | 6.57 |